Stem cells harvested from dental pulp could be the next trend in regenerative medicine for anti-aging and treating chronic skin conditions such as psoriasis, suggests a team of students from Wayne State University School of Medicine in a published letter to the editor of the International Journal of Dermatology.
“Through the Skin of Our Teeth: Potential Applications of Dental Pulp Stem Cells to Skin Diseases,” was written as a clinical update for dermatologists to consider by Arif Musa and Sarah Nassar of the Class of 2022; Jenna Yousif’s class of 2023; Judy Hamad, MD, transition year resident of Henry Ford Health; and Department of Dermatology Associate Professor and Residency Program Director Steven Daveluy, MD
The dental pulp is the central part of a tooth, made up of cells, connective tissue and blood vessels. Dental pulp stem cells, or DPSCs, first isolated by scientists in 2002, represent a novel population of adult stem cells with considerable ability to proliferate, self-renew, and differentiate into multiple lineages , “but have not been explored recently,” the students said. .
DPSCs demonstrated superior growth potential compared to stem cells harvested from bone marrow, a 2009 study from the International Journal of Pediatric Dentistry proved.
“DPSCs have been used (in in vivo studies) to treat spinal cord injury, repair infarcted myocardium, modulate autoimmune conditions, and treat diseases of the pancreas, liver, and oral cavity However, the clinical applicability of DPSCs remains limited in humans at present, with only a handful of human studies published in the literature,” they wrote.
Pilot studies have been limited to the treatment of dental pulpitis and pulpal necrosis, concluding that DPSC implantation is safe and effective in small sample sizes.
“When our team presented the idea to Dr. Daveluy, he was happy to collaborate, especially because he told me that he had never heard of DPSCs before this project. I think that’s part of the reason why our paper was accepted by the International Journal of Dermatology – because the use of DPSCs is still very new and under investigation,” Musa said.
Although DPSCs were first isolated nearly two decades ago, the potential therapeutic applications of these stem cells to skin conditions had only recently been explored.
“They did a great job of spotting an area with a lot of potential,” said Dr Daveluy. “When they approached me, I was impressed by the synthesis of the existing literature that they had produced. I will keep an eye on the literature. I hope we will soon have new treatment options for the clinic.